PANTEX-D Capsules(Pantoprazole Sodium 40 mg + Domperidone 30 mg)

PANTEX-D is a dual-action gastro-protective capsule designed to manage acid-related disorders effectively. It combines:

• Pantoprazole Sodium (40 mg): A potent proton pump inhibitor (PPI) that provides long-lasting suppression of gastric acid production, offering relief in conditions like GERD, gastritis, and peptic ulcers.
• Domperidone (30 mg): A prokinetic and antiemetic agent that enhances gastrointestinal motility and helps relieve symptoms like bloating, nausea, and fullness.

This synergistic combination provides rapid and sustained relief from acidity, reflux, and upper gastrointestinal discomfort.

Pharmacokinetics

• Pantoprazole: Rapid absorption with peak plasma levels in 2–2.5 hours; metabolized in the liver; excreted through urine and bile.
• Domperidone: Quickly absorbed; enhanced bioavailability in low-acid environments; undergoes hepatic metabolism; excreted via urine and feces.

Pharmacodynamics

• Pantoprazole: Inhibits the H⁺/K⁺ ATPase enzyme system in gastric parietal cells, reducing acid secretion at the source.
• Domperidone: Blocks dopamine receptors in the gut and brain, enhancing gastric emptying and relieving nausea.

Dosage Information

• Recommended Use: One capsule daily, preferably before meals or as prescribed by a healthcare provider.
• Adjustments: Required in hepatic or renal impairment under medical supervision.

Contraindications

• Known hypersensitivity to Pantoprazole, Domperidone, or any excipients
• Patients with prolactinoma, GI bleeding, or severe liver disease
• Caution in patients with cardiac arrhythmias or electrolyte imbalance

Storage Instructions

• Store below 25°C in a cool, dry place
• Keep away from moisture and direct sunlight
• Keep out of reach of children

Warnings & Precautions

• Avoid long-term use without medical advice
• Regular monitoring recommended in those with liver or kidney issues
• Not advised during pregnancy or lactation unless clearly needed
• Seek medical attention if symptoms persist or worsen