Telprox 50 Tablets(Telmisartan 40 mg + Metoprolol Succinate 47.5 mg ER)

Telprox 50 is a dual-action antihypertensive formulation designed for optimal blood pressure control and cardiovascular protection. It combines:

• Telmisartan (40 mg): A long-acting angiotensin II receptor blocker (ARB) that relaxes blood vessels, lowering blood pressure and reducing the risk of stroke and heart attack.
• Metoprolol Succinate (47.5 mg ER): A cardio-selective beta-blocker in extended-release form that reduces heart rate and cardiac output, helping to manage hypertension and angina.

Together, they offer a comprehensive approach to blood pressure management, especially in patients with comorbid cardiac conditions.

Pharmacokinetics & Pharmacodynamics

• Telmisartan: Rapid absorption; peak plasma levels within 0.5–1 hour; ~50% bioavailability; excreted via bile. Blocks angiotensin II receptors to reduce vasoconstriction and aldosterone secretion.
• Metoprolol Succinate: Extended-release ensures consistent drug levels; metabolized in liver via CYP2D6; primarily excreted in urine. Reduces sympathetic activity by selectively blocking beta-1 receptors.

Dosage Information

• Recommended Dose: One tablet daily, at the same time each day, with or without food.
• Adjust based on patient response and physician’s guidance.

Contraindications

• Hypersensitivity to Telmisartan, Metoprolol, or any formulation ingredient
• Severe bradycardia or heart block (greater than first degree)
• Cardiogenic shock or decompensated heart failure
• Pregnancy (especially second and third trimester)

Storage

• Store below 30°C in a cool, dry place.
• Protect from moisture and direct sunlight.
• Keep out of reach of children.

Warnings & Precautions

• Monitor blood pressure, heart rate, kidney function, and electrolytes periodically.
• Use with caution in patients with hepatic/renal impairment, diabetes, or electrolyte disturbances.
• Avoid abrupt discontinuation to prevent rebound hypertension or worsening angina.
• Not recommended for patients with severe asthma or COPD due to beta-blocker component.