AMLOSEN-5 is a dual-action antihypertensive medication that combines the benefits of:

• Amlodipine (5 mg) – a long-acting calcium channel blocker that relaxes blood vessels, improving blood flow and reducing blood pressure.
• Atenolol (50 mg) – a cardio-selective beta-blocker that lowers heart rate and cardiac workload, helping to control hypertension and manage angina.

This combination ensures effective 24-hour blood pressure control and reduced cardiovascular risk in patients with hypertension or chronic stable angina.

Pharmacokinetics

• Amlodipine: Slowly absorbed, with peak plasma levels in 6–12 hours; half-life of 30–50 hours enables once-daily dosing.
• Atenolol: Rapid absorption with peak levels in 2–4 hours; half-life of 6–9 hours; mainly excreted unchanged in urine.

Pharmacodynamics

• Amlodipine: Reduces vascular resistance by inhibiting calcium influx into smooth muscles.
• Atenolol: Blocks β1-adrenergic receptors, slowing the heart rate and reducing myocardial oxygen demand.

Dosage

• Usual Adult Dose: One tablet daily, taken at the same time each day.
• Dose adjustments should be guided by a physician based on therapeutic response.

Contraindications

• Cardiogenic shock
• Severe bradycardia or hypotension
• Bronchial asthma or severe COPD
• Known hypersensitivity to Amlodipine, Atenolol, or any tablet component

Storage

• Store below 30°C in a cool, dry environment.
• Protect from moisture and light.
• Keep out of reach of children.

Warnings and Precautions

• Monitor blood pressure, heart rate, and signs of heart failure regularly.
• Use with caution in patients with liver or kidney impairment.
• Discontinue Atenolol gradually to avoid rebound effects such as tachycardia or hypertension.
• Not recommended during pregnancy or breastfeeding unless clearly necessary.
• Always consult a healthcare provider for personalized medical advice.